CLARITY – ChiLdhood Arthritis Risk factor Identification sTudY
نویسندگان
چکیده
منابع مشابه
CLARITY – ChiLdhood Arthritis Risk factor Identification sTudY
UNLABELLED BACKGROUND The aetiology of juvenile idiopathic arthritis (JIA) is largely unknown. We have established a JIA biobank in Melbourne, Australia called CLARITY - ChiLdhood Arthritis Risk factor Identification sTudY, with the broad aim of identifying genomic and environmental disease risk factors. We present here study protocols, and a comparison of socio-demographic, pregnancy, birth...
متن کاملCLARITY: ChiLdhood Arthritis Risk Factor Identification STudY. Investigating the role of aberrant DNA methylation in juvenile idiopathic arthritis
Background Juvenile Idiopathic Arthritis (JIA) is a complex autoimmune disorder likely to be determined by multiple genetic and environmental factors. Mounting evidence shows that epigenetic variation influences autoimmune disease risk. The most well-studied epigenetic mark is DNA methylation; increased methylation of CpG dinucleotides can reduce gene expression. Nothing is currently known abou...
متن کاملHLA studies in IgM rheumatoid-factor-positive arthritis of childhood.
The clinical course of children with IgM rheumatoid-factor-positive chronic arthritis closely resembles that of seropositive rheumatoid disease in adults. The frequency of HLA DR4 is known to be increased in adults with seropositive rheumatoid arthritis, but the first major report on childhood arthritis did not suggest a correlation, though only 8 seropositive cases were included. Fifty-two chi...
متن کاملSuboptimal cardiovascular risk factor identification and management in patients with rheumatoid arthritis: a cohort analysis
INTRODUCTION Accelerated cardiovascular (CV) disease significantly contributes to increased mortality in rheumatoid arthritis (RA) patients, with a risk comparable to the one observed in patients with type 2 diabetes mellitus (DM). Part of this enhanced risk in RA is attributed to traditional cardiovascular risk factors (CRFs). The aims of this study were to determine how often traditional CRFs...
متن کاملTraumatic experiences in childhood and the risk of arthritis: a prospective cohort study.
BACKGROUND Recent data suggest that psychosocial factors, including childhood and adulthood stressors, may play a significant role in the development of chronic musculoskeletal pain and other symptoms. The purpose of this study was to determine if traumatic experiences in childhood are associated with an increased risk of self-reported arthritis later in life. METHODS We used longitudinal dat...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Pediatric Rheumatology
سال: 2012
ISSN: 1546-0096
DOI: 10.1186/1546-0096-10-37